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Josh Yelon's Low-Carb Medical Research

NOTE: All information on this page and the medline links
prepared by Josh Yelon. It is preserved here with his permission.
Volunteers wanted to continue upgrading research compiling and interpretation.


The purpose of this page is to collect a lot of medical research about low-carbohydrate diets in one place, and to make that research understandable to the average person. What you'll find below are abstracts (short summaries) of medical articles. If you click on an entire topic, you'll find several articles, and each article will be followed by an explanation in relatively jargon-free English. Bear in mind, the explanations were not written by a medical professional. There are almost certainly errors in some of them. Please refer to the original article when in doubt, and mail me if you find an error. research@thewhoosh.org


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Pick a topic:

  1. Effectiveness of Low-Carb Diet for Weight Loss

  2. Effects of Low-Carb Diet on the Heart and Arteries

  3. Whether Low-Carb Diets Cause Muscle Deterioration or Not

  4. Effects of Low-Carb Diet on Metabolic Rate

  5. Effects of Low-Carb Diet on the Kidneys

  6. Effects of Low-Carb Diet on the Brain

  7. How Carbohydrate Addiction Happens

  8. Experiments using Low-Carb to Treat Cancer

  9. What was wrong with those old "Liquid Protein" Diets

  10. Effects of Combining Low-Carb with Starvation

  11. Technical Studies about Ketones and their Function in the Body

  12. Articles that I haven't classified yet

    Pick an individual article:

    1. Changes in macronutrient selection as a function of dietary tryptophan. White PJ, Cybulski KA, Primus R, Johnson DF, Collier GH, Wagner GC. Rutgers, State University of New Jersey, New Brunswick 08903. Physiol Behav 1988;43(1):73-77

    2. Loss of weight, sodium and water in obese persons consuming a high- or low-carbohydrate diet. Rabast U, Vornberger KH, Ehl M Ann Nutr Metab 1981;25(6):341-349

    3. The significance of carbohydrates in reducing diets. Article in German. Zwiauer K. Universitats-Kinderklinik Wien. Infusionstherapie 1989 Aug;16(4):176-181

    4. Health effects of trans fatty acids. Ascherio A, Willett WC. Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. Am J Clin Nutr 1997 Oct;66(4 Suppl):1006S-1010S

    5. The human metabolic response to chronic ketosis without caloric restriction: preservation of submaximal exercise capability with reduced carbohydrate oxidation. Phinney SD, Bistrian BR, Evans WJ, Gervino E, Blackburn GL Metabolism 1983 Aug;32(8):769-776

    6. The regulation of ketogenesis. Foster DW, McGarry JD Ciba Found Symp 1982;87:120-131

    7. Effect of a very-low-calorie diet on body composition and resting metabolic rate in obese men and women. Burgess NS. Center for Exercise Science and Cardiovascular Research, Northeastern Illinois University, Chicago 60625. J Am Diet Assoc 1991 Apr;91(4):430-434

    8. The effect of fat composition of the diet on energy metabolism. van Marken Lichtenbelt WD, Mensink RP, Westerterp KR. Department of Human Biology University of Limburg, Maastricht, The Netherlands. Medline record in process. Ernahrungswiss 1997 Dec;36(4):303-305

    9. The human metabolic response to chronic ketosis without caloric restriction: physical and biochemical adaptation. Phinney SD, Bistrian BR, Wolfe RR, Blackburn GL Metabolism 1983 Aug;32(8):757-768

    10. The Effects of a High-protein, Low-fat, Ketogenic Diet on Adolescents With Morbid Obesity: Body Composition, Blood Chemistries, and Sleep Abnormalities. Willi SM, Oexmann MJ, Wright NM, Collop NA, Key LL Jr. Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina. Record supplied by publisher. Pediatrics 1998 Jan 1;101(1):61-67

    11. Protein metabolism in obese patients during very low-calorie mixed diets containing different amounts of proteins and carbohydrates. Pasquali R, Casimirri F, Melchionda N Institute of Clinical Medicine 1, S. Orsola Hospital, University of Bologna, Italy. Metabolism 1987 Dec;36(12):1141-1148

    12. The transient hypercholesterolemia of major weight loss. Phinney SD, Tang AB, Waggoner CR, Tezanos-Pinto RG, Davis PA Am J Clin Nutr 1991 Jun;53(6):1404-1410

    13. Vigorous supplementation of a hypocaloric diet prevents cardiac arrhythmias and mineral depletion. Amatruda JM, Biddle TL, Patton ML, Lockwood DH Am J Med 1983 Jun;74(6):1016-1022

    14. Effect of chronic dietary protein intake on the renal function in healthy subjects. Brandle E, Sieberth HG, Hautmann RE Department of Urology, University of Ulm, Germany. Eur J Clin Nutr 1996 Nov;50(11):734-740

    15. Renal, metabolic and hormonal responses to ingestion of animal and vegetable proteins. Kontessis P, Jones S, Dodds R, Trevisan R, Nosadini R, Fioretto P, Borsato M, Sacerdoti D, Viberti G. Unit for Metabolic Medicine, United Medical School, Guy's Hospital, London, United Kingdom. Kidney Int 1990 Jul;38(1):136-144

    16. Glucose utilization and nitrogen balance in the obese on a protein-lipid hypocaloric diet. Reid D, Rasio E Can J Physiol Pharmacol 1982 Mar;60(3):319-323

    17. The mechanisms of nitrogen sparing in fasting supplemented by protein and carbohydrate. Bistrian BR, Sherman M, Young V J Clin Endocrinol Metab 1981 Oct;53(4):874-878

    18. Effects of dietary protein restriction on the progression of moderate renal disease in the Modification of Diet in Renal Disease Study. No authors listed. J Am Soc Nephrol 1996 Dec;7(12):2616-2626